TDS | SDS

The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). As these are receptors for the Fc portion of mouse IgG, they may also bind laboratory antibody preparations and products used in a variety of cell analysis protocols such as flow cytometry, immunohistochemistry and functional cell assays. The 2.4G2 antibody is therefore widely used as a pre-treatment reagent to block binding of specific antibodies of interest, e.g. fluorescently conjugated antibodies, to Fc receptors via their Fc domains and contributing to “non-specific” staining.

Recent Publications:

Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D, Börgeson E, Singh R, Pessin J, Zang X. The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development. Sci Adv. 2022 Apr 29;8(17):eabm7012. doi: 10.1126/sciadv.abm7012. Epub 2022 Apr 27. PMID: 35476450; PMCID: PMC9045715.

Name	Purified Anti-Mouse CD16 / CD32 (Fc Shield) (2.4G2)
Cat. No.	70-0161
Alternative Names	FCGR3, IGFR3; FCGR2, IGFR2; FC Receptor
Gene ID	14130/14131
Clone	2.4G2
Isotype	Rat IgG2b
Reactivity	Mouse
Format	Purified
Application	Flow Cytometry, IF, IP

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