TDS | SDS

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Name	Purified Anti-Mouse CD152 (CTLA-4) (UC10-4F10-11)
Cat. No.	70-1522
Alternative Names	Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4), Ly-56
Gene ID	12477
Clone	UC10-4F10-11
Isotype	Armenian Hamster IgG
Reactivity	Mouse
Format	Purified
Application	Flow Cytometry

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