TDS | SDS

The IM7 antibody recognizes CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organization, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or “standard” form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion.

The IM7 antibody may be used for detection of all isoforms of CD44, as it recognizes constant epitopes near the extracellular proximal domain. (Xu et al, 2002, J. Leukoc. Biol. 72:1133-1141). It has been reported to be cross-reactive with many non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus, Horse, Cow, Pig, Dog and Cat CD44.

Recent Citations:

Wilfahrt D, Philips RL, Lama J, Kizerwetter M, Shapiro MJ, McCue SA, Kennedy MM, Rajcula MJ, Zeng H, Shapiro VS. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. Elife. 2021 Dec 2;10:e70978. doi: 10.7554/eLife.70978. PMID: 34854376; PMCID: PMC8639145.

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Name	violetFluor™ 450 Anti-Human/Mouse CD44 (IM7)
Cat. No.	75-0441
Alternative Names	Pgp-1, MDU3, Hermes, Hyaluronate receptor
Gene ID	12505
Clone	IM7
Isotype	Rat IgG2b, κ
Reactivity	Human, Mouse
Cross Reactivity	Baboon, Canine, Chimpanzee, Cynomolgus, Equine, Feline, Rhesus, Swine
Format	violetFluor™ 450
Application	Flow Cytometry

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