TDS | SDS

The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex. Together with CD3 gamma, CD3 delta and CD3 zeta, CD3 epsilon assembles to form the CD3 complex that associates with the T cell receptor (TCR). Along with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte development and on all mature T cells.

The UCHT1 antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of UCHT1 antibody to CD3e can induce cell activation (use format suitable for functional assays).

Name

violetFluor™ 500 Anti-Human CD3 (UCHT1)

Cat. No.

85-0038

Alternative Names

Leu-4, T3

Gene ID

915

Clone

UCHT1

Isotype

Mouse IgG1, kappa

Reactivity

Human

Cross Reactivity

Chimpanzee

Format

violetFluor™ 500

Application

Flow Cytometry

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