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The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.

The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161.

Name	Purified Anti-Human CD161 (HP-3G10)
Cat. No.	70-1619
Alternative Names	NKR-P1A, NKRP1A
Gene ID	3820
Clone	HP-3G10
Isotype	Mouse IgG1, kappa
Reactivity	Human
Cross Reactivity	Chimpanzee, Baboon, Rhesus
Format	Purified
Application	Flow Cytometry, Western Blot

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