TDS | SDS

The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte “rolling” on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin αfamily of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.

The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.

Name	redFluor™ 710 Anti-Mouse CD62L (L-Selectin) (MEL-14)
Cat. No.	80-0621
Alternative Names	LECAM-1, Ly-22
Gene ID	20343
Clone	MEL-14
Isotype	Rat IgG2a, κ
Reactivity	Mouse
Format	redFluor™ 710
Application	Flow Cytometry

Request a Demo or a Quote

Your contact information:

Product Information:

Tags

Our use of cookies

Analytics Cookies