Why is Inflammatory Disease Research Important?
For healthy individuals, the immune system effectively identifies unwelcome microorganisms and unhealthy cells to purge them from the host. However, for individuals suffering from an inflammatory disease, the immune system is malfunctioning and attacking healthy cells and tissues. There are hundreds of inflammatory diseases, some of the more commonly known ones include asthma, lupus, rheumatoid arthritis, inflammatory bowel disease, Alzheimer’s disease, and multiple sclerosis.
Cures for many of these diseases remain undiscovered, and better treatments to make the disease manageable and extend the patient’s longevity are needed. To make these discoveries possible, scientists need access to technologically advanced, powerful research solutions.
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Complete the fields below to view the Cytek user group meeting presentation by Achilleas Floudas High Dimensional Flow Cytometric Analysis of Rheumatoid Arthritis Patient Synovial Biopsies. Check the consent boxes at the end of the form to receive additional communication from the Cytek Biosciences team.
Cytek Solutions Enable the World’s Most Cutting Edge Inflammatory Disease Research.
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In Dr. Makoto Inoue’s research lab at the University of Illinois at Urbana-Champaign (UIUC), researchers are trying to determine how environmental triggers and early life trauma (ELT) impact long-term outcomes for individuals suffering from multiple sclerosis. Using a mouse model for experimental autoimmune encephalomyelitis (EAE) and a healthy control model, they raised mice and exposed part of each population to ELT. Blood, bone marrow, and a variety of body tissues were characterized using cellular, proteomic, and genomic tools like immunohistochemistry, western blotting, flow cytometry with Cytek’s Aurora, ELISA, qPCR, and more.
They found that ELT alters immune cell phenotypes in EAE-stricken mice and discovered factors that may enable them to predict long-term outcomes for individuals with multiple sclerosis.
For more information about this research, readMakoto’s publication.
Research Workflow
Autoimmunity Research at Stanford University
Tobias Lanz and Katherine Murphy in Dr. William Robinson’s research group at Stanford University explored expression levels of immune checkpoint receptors for autoimmune disease therapies. The scientists developed multiple high-parameter flow cytometry panels for the Cytek Aurora to characterize and compare immune cell phenotypes across healthy individuals, multiple sclerosis patients, and lupus patients. They found differences between the three groups, specifically differences in receptors expressed in some T cell and B cell subsets that could be viable targets for new therapeutics.
For more information about this research, read Tobias’s publication.
Research Workflow
