TDS | SDS

The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of dendritic cells.

The BC96 antibody may be used as a marker for expression of CD25 during T and B cell development, on activated mature T and B cells, and for its expression at high levels on natural T regulatory cells (nTreg cells) in the thymus or periphery, and on “induced” peripheral Tregs. This antibody is cross-reactive with CD25 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus.

Name	Purified Anti-Human CD25 (BC96)
Cat. No.	70-0259
Alternative Names	Interleukin-2 Receptor alpha, IL-2Rα, IL2Ra, Tac
Gene ID	3559
Clone	BC96
Isotype	Mouse IgG1, kappa
Reactivity	Human
Cross Reactivity	Baboon, Chimpanzee, Cynomolgus, Rhesus
Format	Purified
Application	Flow Cytometry

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