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violetFluor™ 500 Anti-Human/Mouse CD45R (B220) (RA3-6B2)

violetFluor™ 500 Anti-Human/Mouse CD45R (B220) (RA3-6B2)

SKU 85-0452-U025
Regular price

$76.00

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Description

TDS | SDS

The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of ≥ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others.

The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.

Name violetFluor™ 500 Anti-Human/Mouse CD45R (B220) (RA3-6B2)
Cat. No. 85-0452
Alternative Names Ly-5, Lyt-4, T200
Gene ID 19264
Clone RA3-6B2
Isotype Rat IgG2a, κ
Reactivity Mouse
Cross Reactivity Feline
Format violetFluor™ 500
Application
Flow Cytometry
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