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C57Bl/6 bone marrow cells were stained with APC Anti-Mouse CD45R (B220) (20-0452) and 0.125 ug violetFluor™ 500 Anti-Mouse CD11b (85-0112) (right panel) or 0.125 ug violetFluor™ 500 Rat IgG2b isotype control (left panel).

violetFluor™ 500 Anti-Human/Mouse CD11b (M1/70)

SKU 85-0112-U025
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The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

Name violetFluor™ 500 Anti-Human/Mouse CD11b (M1/70)
Cat. No. 85-0112
Alternative Names CD11, Mac-1, integrin αM, CR3, ITGAM
Gene ID 16409 / 3684
Clone M1/70
Isotype Rat IgG2b, κ
Reactivity Human, Mouse
Cross Reactivity Chimpanzee, Baboon, Cynomolgus, Rhesus
Format violetFluor™ 500
Application Flow Cytometry
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