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C57Bl/6 splenocytes were stained with PE Anti-Mouse NK1.1 and 0.125 ug violetFluor™ 450 Anti-Mouse KLRG1 (75-5893) (right panel) or 0.125 ug violetFluor™ 450 Golden Syrian Hamster IgG (left panel).

violetFluor™ 450 Anti-Mouse KLRG1 (2F1)

SKU 75-5893-U025
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The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.

Name violetFluor™ 450 Anti-Mouse KLRG1 (2F1)
Cat. No. 75-5893
Alternative Names MAFA
Gene ID 50928
Clone 2F1
Isotype Golden Syrian Hamster IgG
Reactivity Mouse
Format violetFluor™ 450
Application Flow Cytometry
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