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Human peripheral blood lymphocytes were stained with PerCP-Cy5.5 Anti-Human CD4 (65-0048) and 5 uL (0.5 ug) violetFluor™ 450 Anti-Human CD161 (75-1619) (right panel) or 0.5 ug violetFluor™ 450 Mouse IgG1 isotype control (left panel).

violetFluor™ 450 Anti-Human CD161 (HP-3G10)

SKU 75-1619-T025
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$97.00

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Description

TDS | SDS

The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.

The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161.

Name violetFluor™ 450 Anti-Human CD161 (HP-3G10)
Cat. No. 75-1619
Alternative Names NKR-P1A, NKRP1A
Gene ID 3820
Clone HP-3G10
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Chimpanzee, Baboon, Rhesus
Format violetFluor™ 450
Application Flow Cytometry
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