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C57Bl/6 splenocytes were stained with PE Anti-Mouse CD3e (50-0031) and 0.125 ug redFluor™ 710 Anti-Mouse NK1.1 (CD161) (80-5941) (right panel) or 0.125 ug redFluor™ 710 Mouse IgG2a isotype control (left panel).

redFluor™ 710 Anti-Mouse NK1.1 (CD161) (PK136)

SKU 80-5941-U025
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$58.00

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Description

TDS | SDS

The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).

The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).

Name redFluor™ 710 Anti-Mouse NK1.1 (CD161) (PK136)
Cat. No. 80-5941
Alternative Names CD161, NKR-P1C, Ly-55
Gene ID 17059
Clone PK136
Isotype Mouse IgG2a, κ
Reactivity Mouse
Format redFluor™ 710
Application Flow Cytometry
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