TDS | SDS

The IM7 antibody recognizes CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organization, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or “standard” form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion.

The IM7 antibody may be used for detection of all isoforms of CD44, as it recognizes constant epitopes near the extracellular proximal domain. (Xu et al, 2002, J. Leukoc. Biol. 72:1133-1141). It has been reported to be cross-reactive with many non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus, Horse, Cow, Pig, Dog and Cat CD44.

Recent Citations:

Kwon DI, Park ES, Kim M, Choi YH, Lee MS, Joo SH, Kang YW, Lee M, Jo SB, Lee SW, Kim JK, Lee YJ. Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival. Nat Commun. 2022 Mar 17;13(1):1418. doi: 10.1038/s41467-022-29032-x. PMID: 35301301.

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