Shopping Cart
Human peripheral blood lymphocytes were stained with violetFluor™ 450 Anti-Human CD8 (75-0087) and 5 uL (0.5 ug) redFluor™ 710 Anti-Human CD4 (80-0049) (right panel) or 0.5 ug redFluor™ 710 Mouse IgG1 isotype control (left panel).

redFluor™ 710 Anti-Human CD4 (RPA-T4)

SKU 80-0049-T025
Regular price

$88.00

task_alt Added to cart.
View Cart or Continue shopping.
Description

TDS | SDS

The RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).

Name redFluor™ 710 Anti-Human CD4 (RPA-T4)
Cat. No. 80-0049
Alternative Names Leu-3, T4
Gene ID 920
Clone RPA-T4
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Chimpanzee
Format redFluor™ 710
Application Flow Cytometry
Shipping
Price calculated at checkout.