Shopping Cart
Purified Anti-Mouse CD28 (37.51)

Purified Anti-Mouse CD28 (37.51)

SKU 70-0281-U025
Regular price


task_alt Added to cart.
View Cart or Continue shopping.


The 37.51 antibody reacts with mouse CD28, a 45 kDa glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of co-stimulatory receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

The 37.51 may be used as a phenotypic marker for CD28, which is expressed on all CD4+ T cells and CD8+ T cells, and on NK cells in mouse. In addition, the 37.51 antibody is widely used to activate the CD28 receptor in vitro and in vivo. Please choose the appropriate format for each application.


Recent Publications:

Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 Jun 3;4(1):685. doi: 10.1038/s42003-021-02229-4. PMID: 34083739; PMCID: PMC8175379.

» View on Communications Biology

Castillo-González R, Cibrian D, Fernández-Gallego N, Ramírez-Huesca M, Saiz ML, Navarro MN, Fresno M, Fuente H, Sánchez-Madrid F. Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity. J Invest Dermatol. 2020 Nov 9:S0022-202X(20)32281-8. doi: 10.1016/j.jid.2020.10.020. PMID: 33181141.

» View on ScienceDirect

Name Purified Anti-Mouse CD28 (37.51)
Cat. No. 70-0281
Alternative Names Tp44, T44
Gene ID 12487
Clone 37.51
Isotype Golden Syrian Hamster IgG
Reactivity Mouse
Format Purified
Application Flow Cytometry, IP
Price calculated at checkout.