The mouse monoclonal antibody clone 1D11 binds to human CD314, a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on NK cells, CD8 T cells, γ/δ T cells, and in vitro-induced LAK cells. Several molecules have been identified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, but it participates in signaling this by non-covalent association with DAP10 or DAP12 adaptors. In addition to being a primary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCR-mediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligands plays a role in immune surveillance against pathogen and tumor cells, as well as in the pathogenesis of autoimmune diseases.

PRODUCT DETAILS

Clone: 1D11

Specificity: CD314 (NKG2D)

Reactivity: Human, African Green, Baboon, Cynomolgus Monkey, Rhesus Macaque

Format: Purified

Isotype: Mouse IgG1, k

Application: FC, IP, FUNC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: Recommended dilution: 1-4 μg/ml.

For research use only. Not intended for use in diagnostic procedures.