Purified Anti-Human CD141 (M80)
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Description
The mouse monoclonal antibody clone M80 binds to human CD141, a 75-kDa type I membrane glycoprotein. CD141, also known as thrombomodulin, BDCA-3, and fetomodulin. CD141 binds to its ligand, thrombin, to form a thrombin-thrombomodulin complex. This complex activates protein C and initiates the Protein C anticoagulant pathway. When bound to CD141, thrombin loses its ability to activate several pro-coagulant proteins. The molecule is expressed on macrophages, monocytes, dendritic cells, and vascular endothelial cells.
PRODUCT DETAILS
Clone: M80
Specificity: CD141
Reactivity: Human
Format: Purified
Isotype: Mouse IgG1, k
Application: FC
Storage: 2-8°C protected from light.Do not freeze
Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
RECOMMENDED USAGE
Flow cytometry: Recommended dilution: 1-5 µg/ml
For research use only. Not intended for use in diagnostic procedures.