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C57Bl/6 splenocytes were stained with 0.125 ug PerCP-Cy5.5 Anti-Mouse TCR beta (65-5961) (solid line) or 0.125 ug PerCP-Cy5.5 Armenian hamster IgG isotype control (dashed line).

PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597)

SKU 65-5961-U025
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The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.

The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.


Recent Citations:

Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

» View on Nature Communications

Name PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597)
Cat. No. 65-5961
Alternative Names TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR
Gene ID 21577
Clone H57-597
Isotype Armenian Hamster IgG
Reactivity Mouse
Format PerCP-Cyanine5.5
Application Flow Cytometry
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