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C57Bl/6 splenocytes were stained with 0.125 ug PerCP-Cy5.5 Anti-Mouse CD8a (65-1886) (solid line) or 0.125 ug PerCP-Cy5.5 Rat IgG2b isotype control (dashed line).

PerCP-Cyanine5.5 Anti-Mouse CD8a (2.43)

SKU 65-1886-U025
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$81.00

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Description

TDS | SDS

The 2.43 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.

The 2.43 antibody is widely used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

 

Recent Citations:

Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. T lymphocyte depletion ameliorates age-related metabolic impairments in mice. Geroscience. 2021 Apr 24. doi: 10.1007/s11357-021-00368-4. PMID: 33893902.

» View on PubMed

Name PerCP-Cyanine5.5 Anti-Mouse CD8a (2.43)
Cat. No. 65-1886
Alternative Names CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Gene ID 12525
Clone 2.43
Isotype Rat IgG2b
Reactivity Mouse
Format PerCP-Cyanine5.5
Application Flow Cytometry
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