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C57Bl/6 splenocytes were stained with 0.125 ug PerCP-Cy5.5 Anti-Mouse CD19 (65-0193) (solid line) or 0.125 ug PerCP-Cy5.5 Rat IgG2a isotype control (dashed line).

PerCP-Cyanine5.5 Anti-Mouse CD19 (1D3)

SKU 65-0193-U025
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$47.00

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Description

TDS | SDS

The 1D3 antibody reacts with mouse CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 and CD81, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells. The 1D3 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.

 

Recent Citations:

Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Name PerCP-Cyanine5.5 Anti-Mouse CD19 (1D3)
Cat. No. 65-0193
Alternative Names Leu-12, B4
Gene ID 12478
Clone 1D3
Isotype Rat IgG2a, κ
Reactivity Mouse
Format PerCP-Cyanine5.5
Application Flow Cytometry
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