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C57Bl/6 splenocytes were stained with FITC Anti-Mouse CD3 and 0.25 ug PerCP-Cy5.5 Anti-Mouse CD127 (65-1271) (right panel) or 0.25 ug PerCP-Cy5.5 Rat IgG2a isotype control (left panel).

PerCP-Cyanine5.5 Anti-Mouse CD127 (IL-7Ra) (A7R34)

SKU 65-1271-U025
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$54.00

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Description

TDS | SDS

The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.

The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

Name PerCP-Cyanine5.5 Anti-Mouse CD127 (IL-7Ra) (A7R34)
Cat. No. 65-1271
Alternative Names Interleukin-7 Receptor alpha, IL-7Ra
Gene ID 16172
Clone A7R34
Isotype Rat IgG2a, κ
Reactivity Mouse
Format PerCP-Cyanine5.5
Application Flow Cytometry
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