IL-22 is a cytokine that is structurally related to IL-10. Originally identified as a murine gene induced by IL-9 in T and mast cells, IL-22 was initially designated ILTIF, also known as the IL-10-related T cell-derived inducible factor. IL-22 belongs to a family of cytokines with limited homology specifically to IL-10, IL-19, IL-20, IL-24, IL-26, the IFN-λs, IL-28A, IL-28B, and IL-29. Human IL-22 shares 79% amino acid identity with murine IL-22 and 25% identity with human IL-10. IL-22 biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains. Its activity is further regulated through interactions with the soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II cytokine receptor family. Two types of IL-22 binding receptors have been discovered: a membrane-bound receptor and a soluble receptor that are encoded by different genes. IL-22 is produced by Th17 cells and Th22 cells. The use of Iscove's Modified Dulbecco's Medium (IMDM) will result in better in vitro Th17 polarization. It plays a critical role in mucosal immunity in addition to the deregulated inflammation observed in autoimmune diseases.

PRODUCT DETAILS

Clone: 2G12A41

Antibody Type: Monoclonal

Reactivity: Human

Format: PerCP-Cyanine5.5

Host: Mouse

Isotype: IgG2a, κ

Applications: ICFC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

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