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Human peripheral blood lymphocytes were stained with 5 uL (0.125 ug) PerCP-Cy5.5 Anti-Human CD28 (65-0289) (solid line) or 0.125 ug PerCP-Cy5.5 Mouse IgG1 isotype control (dashed line).

PerCP-Cyanine5.5 Anti-Human CD28 (CD28.2)

SKU 65-0289-T025
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$98.00

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Description

TDS | SDS

The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo (use format suitable for functional assays). This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus.

Name PerCP-Cyanine5.5 Anti-Human CD28 (CD28.2)
Cat. No. 65-0289
Clone CD28.2
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Baboon, Chimpanzee, Cynomolgus, Rhesus
Format PerCP-Cyanine5.5
Application Flow Cytometry
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