The Armenian hamster monoclonal antibody clone 145-2C11 binds to mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, CD3 gamma, and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR) and the CD3 zeta chain to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex recognizes antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including, proliferation, differentiation, production of cytokines, or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

PRODUCT DETAILS

Clone: 145-2C11

Specificity: CD3e

Reactivity: Mouse

Format: PerCP

Isotype: Armenian Hamster IgG

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 2-5 μg/ml. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.

REFERENCES

1. Leo O, et al. 1987.Proc. Natl. Acad. Sci USA. 84:1374-8.

For research use only. Not intended for use in diagnostic procedures.