DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α₂ integrin, VLA-2 α chain, and integrin α₂ chain. CD49b non-covalently associates with CD29 (β₁ integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

PRODUCT DETAILS

Clone: DX5

Antibody Type: Monoclonal

Reactivity: Mouse

Format: PE-Dazzle594

Host: Rat

Isotype: IgM, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.