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C57Bl/6 splenocytes were stained with 0.25 ug PE-Cy7 Anti-Mouse C8a (60-1886) (solid line) or 0.25 ug PE-Cy7 Rat IgG2b isotype control (dashed line).

PE-Cyanine7 Anti-Mouse CD8a (2.43)

SKU 60-1886-U025
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The 2.43 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.

The 2.43 antibody is widely used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Recent Publications:

Nguyen NH, Glassman FY, Dingman RK, Shenoy GN, Wohlfert EA, Kay JG, Bankert RB, Balu-Iyer SV. Rational design of a nanoparticle platform for oral prophylactic immunotherapy to prevent immunogenicity of therapeutic proteins. Sci Rep. 2021 Sep 8;11(1):17853. doi: 10.1038/s41598-021-97333-0. PMID: 34497305; PMCID: PMC8426360.

» View on PubMed

Wu J and Waxman DJ. 2015. OncoImmunol. DOI:10.1080/2162402X.2015.1005521. (Flow Cytometry)

Name PE-Cyanine7 Anti-Mouse CD8a (2.43)
Cat. No. 60-1886
Alternative Names CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Gene ID 12525
Clone 2.43
Isotype Rat IgG2b
Reactivity Mouse
Format PE-Cyanine7
Application Flow Cytometry
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