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C57Bl/6 splenocytes were stained with 0.06 ug PE-Cy7 Anti-Mouse CD62L (60-0621) (solid line) or 0.06 ug Rat IgG2a APC isotype control (dashed line).

PE-Cyanine7 Anti-Mouse CD62L (L-Selectin) (MEL-14)

SKU 60-0621-U025
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The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte “rolling” on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin αfamily of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.

The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.


Recent Citations:

Mergaert AM, Denny MF, Kingstad-Bakke B, Bawadekar M, Bashar SJ, Warner TF, Suresh M, Shelef MA. Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses. J Immunol Res. 2022 Jan 17;2022:5258221. doi: 10.1155/2022/5258221. PMID: 35083342; PMCID: PMC8786467.

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Name PE-Cyanine7 Anti-Mouse CD62L (L-Selectin) (MEL-14)
Cat. No. 60-0621
Alternative Names LECAM-1, Ly-22
Gene ID 20343
Clone MEL-14
Isotype Rat IgG2a, κ
Reactivity Mouse
Format PE-Cyanine7
Application Flow Cytometry
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