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C57Bl/6 splenocytes were stained with 0.25 ug PE-Cy7 Anti-Mouse CD19 (60-0193) (solid line) or 0.25 ug PE-Cy7 Rat IgG2a isotype control (dashed line).

PE-Cyanine7 Anti-Mouse CD19 (1D3)

SKU 60-0193-U025
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$44.00

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Description

TDS | SDS

The 1D3 antibody reacts with mouse CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 and CD81, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells. The 1D3 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.

 

Recent Citations:

Hirano KI, Hosokawa H, Koizumi M, et al. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice. Elife. 2021 Aug 12;10:e68227. doi: 10.7554/eLife.68227. PMID: 34382935; PMCID: PMC8360648.

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Name PE-Cyanine7 Anti-Mouse CD19 (1D3)
Cat. No. 60-0193
Alternative Names Leu-12, B4
Gene ID 12478
Clone 1D3
Isotype Rat IgG2a, κ
Reactivity Mouse
Format PE-Cyanine7
Application Flow Cytometry
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