PE-Cyanine7 Anti-Mouse CD19 (1D3)
The 1D3 antibody reacts with mouse CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 and CD81, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells. The 1D3 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.
Hirano KI, Hosokawa H, Koizumi M, et al. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice. Elife. 2021 Aug 12;10:e68227. doi: 10.7554/eLife.68227. PMID: 34382935; PMCID: PMC8360648.
|Name||PE-Cyanine7 Anti-Mouse CD19 (1D3)|
|Alternative Names||Leu-12, B4|
|Isotype||Rat IgG2a, κ|