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Human peripheral blood lymphocytes were stained with 5 uL (0.25 ug) PE-Cy7 Anti-Human CD19 (60-0199) (solid line) or 0.25 ug PE-Cy7 Mouse IgG1 isotype control (dashed line).

PE-Cyanine7 Anti-Human CD19 (HIB19)

SKU 60-0199-T025
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The HIB19 antibody reacts with human CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21, CD81 and CD225, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.

The HIB19 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.

Recent Publications:

Moroney JB, Vasudev A, Pertsemlidis A, Zan H, Casali P. Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells. Nat Commun. 2020 Oct 28;11(1):5435. doi: 10.1038/s41467-020-19242-6. PMID: 33116135.

» View on Nature 

Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020).

Diaz-Flores E, Comeaux EQ, Kim KL, et al. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019;79(9):2339-2351. doi:10.1158/0008-5472.CAN-18-0236.

» View on PubMed

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Laser Therapy. 24(3): 179-188. (Flow Cytometry)

Name PE-Cyanine7 Anti-Human CD19 (HIB19)
Cat. No. 60-0199
Alternative Names Leu-12, B4
Gene ID 930
Clone HIB19
Isotype Mouse IgG1, kappa
Reactivity Human
Format PE-Cyanine7
Application Flow Cytometry
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