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C57Bl/6 splenocytes were stained with 0.5 ug PE-Cy5 Anti-Mouse CD3e (55-0031) (solid line) or 0.5 ug PE-Cy5 Armenian hamster IgG isotype control (dashed line).

PE-Cyanine5 Anti-Mouse CD3e (145-2C11)

SKU 55-0031-U025
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The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

Recent Publications:
Neyt K, GeurtsvanKessel CH and Lambrecht BN. 2015. Mucosal Immunol. DOI 10.1038/mi2015.91. (Flow Cytometry)

Name PE-Cyanine5 Anti-Mouse CD3e (145-2C11)
Cat. No. 55-0031
Alternative Names CD3 epsilon
Gene ID 12501
Clone 145-2C11
Isotype Armenian Hamster IgG
Reactivity Mouse
Format PE-Cyanine5
Application Flow Cytometry
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