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Human peripheral blood lymphocytes were stained with FITC Anti-Human CD8 (35-0088) and 5 uL (0.25 ug) PE-Cyanine5 Anti-Human CD4 (55-0049) (right panel) or 0.25 ug PE-Cyanine5 Mouse IgG1 isotype control (left panel).

PE-Cyanine5 Anti-Human CD4 (RPA-T4)

SKU 55-0049-T025
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The RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).


Name PE-Cyanine5 Anti-Human CD4 (RPA-T4)
Cat. No. 55-0049
Alternative Names Leu-3, T4
Gene ID 920
Clone RPA-T4
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Chimpanzee
Format PE-Cyanine5
Application Flow Cytometry
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