TREM-2 is a 26 kD transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia.

PRODUCT DETAILS

Clone: 6E9

Antibody Type: Monoclonal

Reactivity: Mouse

Format: PE

Host: Rat

Isotype: IgG2b, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

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