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C57Bl/6 splenocytes were stimulated with PMA and Ionomycin (right panel) or unstimulated (left panel) and then stained with APC Anti-Mouse CD3e (20-0031), followed by intracellular staining with 0.06 ug PE Anti-Mouse IL-2 (50-7021).

PE Anti-Mouse IL-2 (JES6-5H4)

SKU 50-7021-U025
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The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.

The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralizing reagent in vitro and in vivo.

Recent Publications:
Brooks A, Jonkman J, Bookmyer Z, and Bruns HA. 2014. Int. J. Herbal Med. 2:13-20. (Flow Cytometry)

Name PE Anti-Mouse IL-2 (JES6-5H4)
Cat. No. 50-7021
Alternative Names Interleukin-2
Gene ID 16183
Clone JES6-5H4
Isotype Rat IgG2b, κ
Reactivity Mouse
Format PE
Application Flow Cytometry
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