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C57Bl/6 splenocytes were unstimulated (left panel) or stimulated for 3 days with LPS (right panel) and stained with 0.125 ug PE Anti-Mouse CD86 (50-0861) (solid line) or 0.125 ug PE Rat IgG2b isotype control (dashed line).

PE Anti-Mouse CD86 (B7-2) (PO3.1)

SKU 50-0861-U025
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$44.00

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Description

TDS | SDS

The PO3.1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response.

The PO3.1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.

 

Recent Citations:

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

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Name PE Anti-Mouse CD86 (B7-2) (PO3.1)
Cat. No. 50-0861
Alternative Names B7.2, B70, Ly-58
Gene ID 12524
Clone PO3.1
Isotype Rat IgG2b, κ
Reactivity Mouse
Format PE
Application Flow Cytometry
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