PE Anti-Mouse CD86 (B7-2) (GL-1)
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The GL-1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response.
The GL-1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.
Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790. (Flow Cytometry)
|Name||PE Anti-Mouse CD86 (B7-2) (GL-1)|
|Alternative Names||B7.2, B70, Ly-58|
|Isotype||Rat IgG2a, κ|