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C57Bl/6 splenocytes were stained with 0.125 ug PE Anti-Mouse CD62L (50-0621) (solid line) or 0.125 ug PE Rat IgG2a isotype control (dashed line).

PE Anti-Mouse CD62L (L-Selectin) (MEL-14)

SKU 50-0621-U025
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$40.00

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Description

TDS | SDS

The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte “rolling” on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin αfamily of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.

The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.

 

Recent Citations:

Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses. J Immunol. 2022 Feb 2:ji2100996. doi: 10.4049/jimmunol.2100996. Epub ahead of print. PMID: 35110421

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Name PE Anti-Mouse CD62L (L-Selectin) (MEL-14)
Cat. No. 50-0621
Alternative Names LECAM-1, Ly-22
Gene ID 20343
Clone MEL-14
Isotype Rat IgG2a, κ
Reactivity Mouse
Format PE
Application Flow Cytometry
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