Macrophage-stimulating 1 receptor (MST1R/RON) is a receptor protein kinase that transduce signals from the extracellular matrix into the cytoplasm by binding to the macrophage-stimulating protein (MSP). MST1R regulates various physiological processes including cell adhesion, motility, growth, and survival. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, it interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. RON plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than the MST1 ligand.

PRODUCT DETAILS

Clone: S20018D

Antibody Type: Monoclonal

Reactivity: Mouse

Format: PE

Host: Rat

Isotype: IgG1, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.