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C57Bl/6 splenocytes were stained with APC Anti-Mouse CD3 and 0.25 ug PE Anti-Mouse CD127 (50-1271) (right panel) or 0.25 ug PE Rat IgG2a isotype control (left panel).

PE Anti-Mouse CD127 (IL-7Ra) (A7R34)

SKU 50-1271-U025
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The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.

The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).


Recent Citations:

Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 May 11;54(5):931-946.e11. doi: 10.1016/j.immuni.2021.03.020. Epub 2021 Apr 9. PMID: 33838102; PMCID: PMC8317508.

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Name PE Anti-Mouse CD127 (IL-7Ra) (A7R34)
Cat. No. 50-1271
Alternative Names Interleukin-7 Receptor alpha, IL-7Ra
Gene ID 16172
Clone A7R34
Isotype Rat IgG2a, κ
Reactivity Mouse
Format PE
Application Flow Cytometry
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