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C57Bl/6 bone marrow cells were stained with APC Anti-Mouse CD45R (B220) (20-0452) and 0.06 ug PE Anti-Mouse CD117 (50-1172) (right panel) or 0.06 ug  PE Rat IgG2b (left panel).

PE Anti-Mouse CD117 (c-Kit) (ACK2)

SKU 50-1172-U025
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The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of ≥≥immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of ≥≥the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of ≥≥c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.

The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo (use format appropriate for functional assays).

Name PE Anti-Mouse CD117 (c-Kit) (ACK2)
Cat. No. 50-1172
Alternative Names Steel Factor Receptor, SCFR, cKit
Gene ID 16590
Clone ACK2
Isotype Rat IgG2b, κ
Reactivity Mouse
Cross Reactivity Rat
Format PE
Application Flow Cytometry
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