TMPRSS2 is a membrane-anchored protein that belongs to the serine protease family and is involved in many physiological and pathological processes. TMPRSS2 participates in proteolytic cascades and is important in normal physiological function of the prostate. Autocleavage leads to secretion of the protease domain. TMPRSS2 is involved in extracellular matrix disruption and metastasis of prostate cancer cells and activates several substrates, including pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14. TMPRSS2 promotes uptake of SARS-CoV-1, MERS-CoV, and SARS-CoV-2 viral particles of by proteolytic cleavage of ACE2 receptor and cleavage of coronavirus spike glycoproteins.

PRODUCT DETAILS

Clone: S20014A

Antibody Type: Monoclonal

Reactivity: Human

Format: PE

Host: Mouse

Isotype: IgG1, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.