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C57Bl/6 bone marrow cells were stained with 0.125 ug Anti-Hu/Mo CD11b PE (50-0112) (solid line) or 0.125 ug Rat IgG2b PE isotype control (dashed line).

PE Anti-Human/Mouse CD11b (M1/70)

SKU 50-0112-U025
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The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

Recent Publications:

Adrover JM, Carrau L, Daßler-Plenker J, Bram Y, Chandar V, Houghton S, Redmond D, Merrill JR, Shevik M, tenOever BR, Lyons SK, Schwartz RE, Egeblad M. Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection. JCI Insight. 2022 Feb 8:e157342. doi: 10.1172/jci.insight.157342. Epub ahead of print. PMID: 35133984.

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Saeki N, Imai Y. Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions. Cell Commun Signal. 2020 Nov 30;18(1):188. doi: 10.1186/s12964-020-00678-8. PMID: 33256735; PMCID: PMC7708128. 

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Velasco-de Andrés M, Català C, Casadó-Llombart S, et al. The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection. Antimicrob Agents Chemother. 2020 Oct 12:AAC.01103-20. doi: 10.1128/AAC.01103-20. PMID: 33046489. 

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Kasashima H, Yashiro M, Nakamae H, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubu N et al. 2015. Br J Cancer. doi: 10.1038/bjc.2015.236. (Flow Cytometry)

Name PE Anti-Human/Mouse CD11b (M1/70)
Cat. No. 50-0112
Alternative Names Mac-1, integrin α?M, CR3, ITGAM
Gene ID 16409 / 3684
Clone M1/70
Isotype Rat IgG2b, κ
Reactivity Human, Mouse
Cross Reactivity Chimpanzee, Baboon, Cynomolgus, Rhesus
Format PE
Application Flow Cytometry
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