Glypican-4 is a cell surface heparan sulfate proteoglycan that contains a core protein anchored to the cytoplasmic membrane via a GPI anchor. Glypicans function as coreceptors for a variety of growth factors including Wnt, bone morphogenetic proteins (BMPs), fibroblast growth factors, and Hedgehog. In particular, Glypican-4 enhances the Wnt3a dependent β-catenin pathway and the Wnt5a-dependent non-canonical Wnt signaling. Glypican-4 plays a role in the control of cell division and growth regulation and is upregulated in pancreatic cancer and colorectal cancer where it is involved in promoting chemoresistance. Glypican-4 also regulates glutamatergic synapse formation and function in the developing brain.

PRODUCT DETAILS

Clone: A21050B

Antibody Type: Monoclonal

Reactivity: Human

Format: Glypican-4

Host: Mouse

Isotype: IgG2b, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.