The antibody LN2 recognizes an extracellular epitope of CD74 (the MHC II-associated invariant chain, Ii), a type II transmembrane protein expressed in antigen-presenting cells, as well as e.g. on activated neoplastic cells in T cell lymphomas, in lymph node germinal center, mantle zone B cells, histiocytes, interdigitating reticulum cells, Langerhans cells, thymic dendritic cells and peripheral blood B lymphocytes.

PRODUCT DETAILS

Clone: LN2

Specificity: CD74

Reactivity: Human

Format: PE

Isotype: Mouse IgG1

Tested Dilution: 5 µL/Test

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 5 µL per 1 million cells in a staining volume of 100 µL. If whole blood is analyzed, then use 5 µL per 100 µL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. The content of a vial (0.5 mL) is sufficient for 100 tests.

REFERENCES

1. Hussain A, et al. 2008. J Virol 82:893-902.
2. Gore Y, et al. 2008. J Biol Chem 283:2784-92.
3. Lantner F, et al. 2007. Blood 110:4303-11.
4. Stein R, et al. 2007. Clin Cancer Res 13:5556s-5563s.
5. Starlets D, et al. 2006. Blood 107:4807-16.
6. Burton JD, et al. 2004. Clin Cancer Res 10:6606-11.
7. Badve S, et al. 2002. J Histochem Cytochem 50:473-82.
8. Leng L, et al. 2003. J Exp Med 197:1467-76.
9. Perez MT, et al. 2002. Arch Pathol Lab Med 126:1534-7.
10. Freeman GJ, et al. 1998. J Immunol 161:2708-15.

For research use only. Not intended for use in diagnostic procedures.