TDS | SDS

The 4H11 monoclonal antibody reacts with human CD34, a single pass transmembrane protein with a molecular weight of 105-120 kDa. CD34 is heavily glycosylated with an N-terminal mucin domain. Although the function of CD34 is not defined, the intracellular domain of CD34 is a target for phosphorylation by activated protein kinase C, suggesting a possible role in signal transduction. CD34 is expressed on hematopoietic progenitor cells, some populations of mesenchymal stem cells, and vascular endothelium. Various epitopes of CD34 have been defined based on their differential sensitivity to enzymatic cleavage. By these criteria, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope. Additionally, CD34 may also function as an adhesion molecule with a role in mediating attachment of stem cells to bone marrow extracellular matrix, stromal cells, or other bone marrow components.