PE Anti-Human CD161 (HP-3G10)
The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.
The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161.
Roa, J.A., Sarkar, D., Zanaty, M. et al. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep 10, 11809 (2020). https://doi.org/10.1038/s41598-020-68861-y.
Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Laser Therapy. 24(3): 179-188. (Flow Cytometry)
|Name||PE Anti-Human CD161 (HP-3G10)|
|Alternative Names||NKR-P1A, NKRP1A|
|Isotype||Mouse IgG1, kappa|
|Cross Reactivity||Chimpanzee, Baboon, Rhesus|