CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.CD158f, also known as KIR2DL5, is a 40 kD two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with an ITIM motif as well as an immunoreceptor tyrosine-based switch motif (ITSM). It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL5 has been reported to bind to CD155 resulting in immune inhibitory suppression of NK cells.4

PRODUCT DETAILS

Clone: S22010E

Antibody Type: Monoclonal

Reactivity: Human

Format: CD158f

Host: Mouse

Isotype: IgG1, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

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