CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.CD158b1 and CD158j, also known as KIR2DL2 and KIR2DS2, respectively, are glycoproteins with two extracellular Ig domains. KIR2DL2 displays a long cytoplasmic tail with ITIM motifs and is 38 kD. KIR2DS2, with a short cytoplasmic tail containing an ITAM motif, is 33 kD in size.  Both KIR2DL2 and KIR2DS2 are expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL2 and KIR2DS2 have been reported to bind to certain HLA-C antigens on a target cell (HLA-C*01, HLA-C*03, HLA-C*07, for example).

PRODUCT DETAILS

Clone: S22032A

Antibody Type: Monoclonal

Reactivity: Human

Format: CD158b1/j

Host: Mouse

Isotype: IgG2b, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.