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Human peripheral blood monocytes were stained with 5 uL (1 ug) PE Anti-Human CD11b (50-0118) (solid line) or 1 ug PE Mouse IgG1 isotype control (dashed line).

PE Anti-Human CD11b (ICRF44)

SKU 50-0118-T025
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The ICRF44 antibody reacts with human CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The ICRF44 antibody is widely used as a marker for CD11b expression on macrophages, granulocytes, and subsets of NK cells. It is reported to be cross-reactive with a number of non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus and Swine.

Name PE Anti-Human CD11b (ICRF44)
Cat. No. 50-0118
Alternative Names Mac-1, integrin ααM, Itgam, CR3
Gene ID 3684
Clone ICRF44
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Baboon, Chimpanzee, Cynomolgus, Rhesus, Swine
Format PE
Application Flow Cytometry
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