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In Vivo Ready™ Anti-Mouse IL-12/IL-23 p40 (C17.8)

In Vivo Ready™ Anti-Mouse IL-12/IL-23 p40 (C17.8)

SKU 40-7123-U100
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The C17.8 antibody is specific for the 40 kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35 kDa protein known as p35, resulting in a 70 kDa functional cytokine. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target naïve, resting CD4+ T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19 kDa protein chain, p19; its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4+ T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the receptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.

As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine. Please choose the appropriate format for each application.

Name In Vivo Ready™ Anti-Mouse IL-12/IL-23 p40 (C17.8)
Cat. No. 40-7123
Data Sheets TDS | SDS
Alternative Names Interleukin-12, IL12 / Interleukin-23, IL23 p40, Cytotoxic lymphocyte maturation factor (CLMF), Natural killer cell stimulatory factor (NKSF), CTL maturation factor (TcMF), T-cell stimulating factor (TSF)
Gene ID 16160
Clone C17.8
Isotype Rat IgG2a, κ
Reactivity Mouse
Format In Vivo Ready™
Application FC - Validated
FA, IF, IP, WB, ELISA - Reported in literature, not validated in house

For Research Use Only. Not intended for use in diagnostic procedures.

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